Fanconi anemia: young patients at high risk for squamous cell carcinoma
نویسندگان
چکیده
منابع مشابه
Fanconi anemia: young patients at high risk for squamous cell carcinoma
BACKGROUND Fanconi anemia is one of the best studied inherited cancer-prone diseases. Greatly improved protocols for hematopoietic stem cell transplantation increasingly save the lives of these young patients. However, in both transplanted and not transplanted patients, the emergence of aggressive squamous cell carcinoma represents a major medical challenge. CONCLUSIONS This mini review summa...
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Fanconi Anemia (FA) is an autosomal recessive disease characterized by chromosome instability, cellular hypersensitivity to DNA cross-linking agents, and increased predisposition to malignancies. We describe here a 28 year-old female with FA and vaginal squamous cell carcinoma treated by radiation therapy alone. The patient developed arm phlebitis, pulmonary fungal infection, and severe rectal ...
متن کاملHead and Neck Squamous Cell Carcinoma in Fanconi Anemia Patients
Head and neck cancers are among the most common tumors to develop in patients with Fanconi anemia.1,2 Although these tumors are histopathologically similar to those in patients without FA, the frequency, distribution, and clinical course are significantly different and must be taken into account when considering cancer management in patients with FA (Table 1). This chapter provides an overview ...
متن کاملdetection of high risk human papillomavirus dna sequences in head and neck squamous cell carcinoma in iranian fanconi anemia patients
background: fanconi anemia (fa) is an autosomal recessive disorder characterized by congenital malformations, bone marrow failure, development of squamous cell carcinoma (scc), and other cancers. human papillomavirus (hpv) in the oral cavity or oropharynx has been associated with an increased risk of laryngeal papillomatosis, invasive squamous cell carcinoma of the head and neck (hnscc) and cer...
متن کاملHigh incidence of head and neck squamous cell carcinoma in patients with Fanconi anemia.
BACKGROUND Fanconi anemia (FA) is a rare autosomal recessive disorder characterized by a high degree of genomic instability and predisposition to cancer development. Recent evidence suggests that the incidence of head and neck squamous cell carcinoma (HNSCC) may be increased in patients with FA. OBJECTIVE To determine the cumulative incidence, tumor distribution, and outcome of HNSCC in patie...
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ژورنال
عنوان ژورنال: Molecular and Cellular Pediatrics
سال: 2014
ISSN: 2194-7791
DOI: 10.1186/s40348-014-0009-8